Histocompatibility Antigens Class I

**Definition:** Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.

**Tree numbers:** - D09.400.430.890.489 - D12.776.395.550.489 - D12.776.543.550.439 - D23.050.301.500.100 - D23.050.705.552.100

**Synonyms:** - Class I Major Histocompatibility Antigens - Class I Histocompatibility Antigens - MHC Class I Molecules - Class I Major Histocompatibility Molecules - MHC-I Molecules - MHC-I Peptides - Class I MHC Proteins - Class I Antigen - Class I Histocompatibility Antigen - Class I MHC Protein - Class I Major Histocompatibility Antigen - MHC Class I Molecule - Class I Antigens - MHC-I Peptide