DNA Topoisomerases, Type II

**Definition:** DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.

**Tree numbers:** - D08.811.399.403.741

**Synonyms:** - DNA Topoisomerase II - Type II DNA Topoisomerase - DNA Type 2 Topoisomerase - DNA Topoisomerase (ATP-Hydrolysing) - Topoisomerase II