DNA Topoisomerase IV

**Definition:** A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.

**Tree numbers:** - D08.811.399.403.741.224 - D12.776.097.256

**Synonyms:** - Topo IV - Topoisomerase IV