HLA-C Antigens

**Definition:** Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).

**Tree numbers:** - D09.400.430.890.489.600 - D12.776.395.550.489.600 - D12.776.543.550.439.600 - D23.050.301.500.100.600 - D23.050.301.500.450.390 - D23.050.705.552.100.600 - D23.050.705.552.450.390

**Synonyms:** - HLA-C - Antigens, HLA-C