Fusion Proteins, bcr-abl

**Definition:** Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.

**Tree numbers:** - D08.811.913.696.620.682.725.500.500 - D12.776.476.568.500.500 - D12.776.602.500.500.100 - D12.776.624.664.500.100 - D12.776.624.664.700.171.500

**Synonyms:** - bcr-abl Fusion Protein - bcr-abl Fusion Proteins - Bcr-Abl Tyrosine Kinase