Proto-Oncogene Proteins c-abl

**Definition:** Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.

**Tree numbers:** - D08.811.913.696.620.682.725.500 - D12.776.476.568.500 - D12.776.624.664.700.167

**Synonyms:** - abl Proto-Oncogene Products - Proto-Oncogene Proteins abl - abl Proto-Oncogene Proteins - c-abl Proteins