Genes, Retinoblastoma

**Definition:** Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.

**Tree numbers:** - G05.360.340.024.340.375.249.400 - G05.360.340.024.340.415.400.400

**Synonyms:** - Genes, Rb - Rb Genes - Retinoblastoma Genes