CD40 Antigens

**Definition:** Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

**Tree numbers:** - D12.776.465.750 - D12.776.543.750.705.852.760.097 - D23.050.301.264.051.140 - D23.101.100.150.140

**Synonyms:** - Tumor Necrosis Factor Receptor Superfamily, Member 5 - TNFRSF5 Receptor - CD40 Antigen - Antigens, CD40 - CDw40 Antigen