Immune Checkpoint Proteins

**Definition:** Immunomodulators that regulate immune system either in stimulatory or inhibitory fashion allowing IMMUNE TOLERANCE. Activation of suppressed immune system (IMMUNOSUPPRESSION (PHYSIOLOGY)) in immunotherapy by IMMUNE CHECKPOINT INHIBITORS often targets inhibitory checkpoint molecules.

**Tree numbers:** - D12.776.465 - D23.383

**Synonyms:** - Immune Checkpoint Molecule - Immune Checkpoint Molecules - Immune Checkpoint Protein