Cytochrome P-450 CYP2D6

**Definition:** A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.

**Tree numbers:** - D08.244.453.005.600 - D08.244.453.491.372 - D08.811.682.690.708.170.010.600 - D08.811.682.690.708.170.450.368 - D12.776.422.220.453.010.600 - D12.776.422.220.453.491.368

**Synonyms:** - Sparteine Monooxygenase - Cytochrome P450 2D6 - Debrisoquine 4-Monooxygenase - Debrisoquine 4-Hydroxylase - Imipramine 2-Hydroxylase - CYP2D6 - CYP 2D6 - Debrisoquine Hydroxylase