Cyclin-Dependent Kinase Inhibitor p16

**Definition:** A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.

**Tree numbers:** - D12.644.360.225.200 - D12.776.167.187.200 - D12.776.476.225.200 - D12.776.624.776.355.200

**Synonyms:** - CDKN2 Protein - CDKN2A Protein - MTS1 Protein - p16INK4 Protein - Cdk4-Associated Protein p16 - p16(INK4A) - INK4A Protein - Cyclin-Dependent Kinase Inhibitor-2A - Multiple Tumor Suppressor-1 - p16INK4A Protein