Brain Diseases, Metabolic, Inborn

**Definition:** Brain disorders resulting from inborn metabolic errors, primarily from enzymatic defects which lead to substrate accumulation, product reduction, or increase in toxic metabolites through alternate pathways. The majority of these conditions are familial, however spontaneous mutation may also occur in utero.

**Tree numbers:** - C10.228.140.163.100 - C16.320.565.189 - C18.452.132.100 - C18.452.648.189

**Synonyms:** - Brain Syndrome, Metabolic, Inborn - Encephalopathies, Metabolic, Inborn - Inborn Errors of Metabolism, Brain - Inborn Metabolic Brain Diseases - Inborn Metabolic Brain Disorders - Inborn Metabolic Disorders, Brain - Metabolic Brain Diseases, Inborn - Metabolic Brain Syndrome, Inborn - Metabolic Diseases, Inborn, Brain