Mitogen-Activated Protein Kinase Kinases

**Definition:** A dual-specific protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.

**Tree numbers:** - D08.811.913.696.620.682.700.565 - D08.811.913.696.620.682.725.200 - D12.776.476.563.565 - D12.776.476.568.200

**Synonyms:** - MAPK Kinase - Map Kinase Kinase - MAPKK - MAP Kinase Kinases - MAPK Kinases - Mitogen-Activated Protein Kinase Kinase - MAPKKs