MAP Kinase Kinase 4

**Definition:** A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.

**Tree numbers:** - D08.811.913.696.620.682.700.565.400 - D08.811.913.696.620.682.725.200.400 - D12.776.476.563.565.400 - D12.776.476.568.200.400

**Synonyms:** - JN Kinase Kinase - JNK Kinase - Jun Amino-Terminal Kinase Kinase - JNK-Activating Protein Kinase - SAP Kinase Kinase 1 - SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1 - SEK1 Protein Kinase - Mitogen-Activated Protein Kinase Kinase 4 - MEK4 Protein Kinase - JNKK1 Protein Kinase - SAPK-ERK Kinase 1 - Stress-Activated Protein Kinase Kinase 1