Genes, BRCA2

**Definition:** A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)

**Tree numbers:** - G05.360.340.024.340.375.249.105 - G05.360.340.024.340.415.400.105

**Synonyms:** - BRCA2 Gene