11-beta-Hydroxysteroid Dehydrogenase Type 2

**Definition:** An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.

**Tree numbers:** - D08.811.682.047.436.174.600 - D08.811.682.047.820.100.600

**Synonyms:** - 11 beta-HSD2 - 11 beta-Hydroxysteroid Dehydrogenase Type 2 - 11beta-HSD2 - 11beta-HSD2 Reductase - 11beta-Hydroxysteroid Dehydrogenase Type 2