Transient Receptor Potential Channels

**Definition:** A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.

**Tree numbers:** - D12.776.157.530.400.901 - D12.776.543.585.400.901

**Synonyms:** - TRP Cation Channel - Transient Receptor Potential Channel - TRP Cation Channels - TRP Membrane Proteins - Transient Receptor Potential Cation Channel - Transient Receptor Potential Cation Channels