E2F Transcription Factors

**Definition:** A family of BASIC HELIX-LOOP-HELIX PROTEINS that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.

**Tree numbers:** - D12.776.930.211

**Synonyms:** - E2F Proteins - E2F Transcription Factor - Transcription Factor E2F