Cyclin-Dependent Kinase Inhibitor p27

**Definition:** A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.

**Tree numbers:** - D12.644.360.225.600 - D12.776.167.187.600 - D12.776.476.225.600 - D12.776.624.776.355.600

**Synonyms:** - CDKN4 Protein - p27 CDK Inhibitor - Cyclin-Dependent Kinase Inhibitor 1B - CDKN1B Protein - p27Kip1 Protein - CDK Inhibitor p27 - p27 Kip1 Protein