Interferon Regulatory Factor-3

**Definition:** An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA, and activates transcription.

**Tree numbers:** - D12.644.360.024.302.374 - D12.776.157.057.050.374 - D12.776.260.504.374 - D12.776.476.024.385.374 - D12.776.744.562 - D12.776.930.332.374

**Synonyms:** - IRF-3 Transcription Factor - IFN-Regulatory Factor 3