p300-CBP Transcription Factors

**Definition:** A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.

**Tree numbers:** - D08.811.913.050.134.415.500.575 - D12.776.930.680

**Synonyms:** - p300-CBP Coactivator - p300-CBP Protein