D051794Level 7

Von Hippel-Lindau Tumor Suppressor Protein

**Definition:** A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.

**Tree numbers:** - D08.811.464.938.750.875 - D12.776.624.776.865

**Synonyms:** - VHL Tumor Suppressor Protein

GET/api/v1/systems/mesh/nodes/D051794

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