B7-2 Antigen

**Definition:** A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN. It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.

**Tree numbers:** - D12.776.465.500 - D12.776.467.150.200 - D12.776.543.095.200 - D23.050.301.285.200 - D23.529.168.200

**Synonyms:** - Early T Cell Costimulatory Molecule 1 - Antigens, CD86 - CD86 Antigens - Antigen, B7-2 - B7-2 Costimulatory Molecule - CD86 Antigen - B70 Costimulatory Molecule