TNF-Related Apoptosis-Inducing Ligand

**Definition:** A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.

**Tree numbers:** - D12.644.276.374.750.625 - D12.776.467.374.750.625 - D23.529.374.750.625

**Synonyms:** - CD253 Antigen - Apo-2 Ligand - TRAIL Protein - Apo-2L Protein - TNF Superfamily, Member 10 - Tumor Necrosis Factor Ligand Superfamily Member 10