Nod2 Signaling Adaptor Protein

**Definition:** A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.

**Tree numbers:** - D12.644.360.024.131.500 - D12.644.360.024.313.500 - D12.644.360.075.358.500 - D12.644.360.539.500.500 - D12.776.157.057.006.500 - D12.776.157.057.078.500 - D12.776.476.024.139.500 - D12.776.476.024.391.500 - D12.776.476.075.358.500

**Synonyms:** - Nucleotide Oligomerization Domain 2 Protein - Caspase Recruitment Domain Protein 15 - CARD15 Protein