Apoptotic Protease-Activating Factor 1

**Definition:** A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.

**Tree numbers:** - D12.644.360.024.131.124 - D12.644.360.075.358.124 - D12.776.157.057.006.124 - D12.776.476.024.139.124 - D12.776.476.075.358.124

**Synonyms:** - Apoptotic Peptidase Activating Factor 1 - Apaf-1 Protease-Activating Factor