Keratoderma, Palmoplantar, Epidermolytic

**Definition:** An autosomal dominant hereditary skin disease characterized by epidermolytic hyperkeratosis that is strictly confined to the palms and soles. It has been associated with mutations in the gene that codes for KERATIN-9.

**Tree numbers:** - C16.320.850.475.440.500 - C17.800.428.435.440.500 - C17.800.827.475.440.500

**Synonyms:** - Unna-Thost Disease, Epidermolytic - EPPK (Epidermolytic Palmoplantar Keratoderma) - Thost-Unna Disease, Epidermolytic - Palmoplantar Keratoderma, Epidermolytic - Keratoderma, Epidermolytic Palmoplantar - Hyperkeratosis, Localized Epidermolytic