Sirtuin 1

**Definition:** A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.

**Tree numbers:** - D08.811.277.087.520.200.650.100 - D12.776.476.900.100

**Synonyms:** - Silent Mating Type Information Regulation 2 Homolog 1 - Sirt1