Nuclear Receptor Subfamily 1, Group D, Member 1

**Definition:** A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.

**Tree numbers:** - D12.776.260.643.080 - D12.776.476.156.300 - D12.776.826.209.080

**Synonyms:** - Rev-erb-alpha Nuclear Receptors - Nuclear Receptor NR1D1 - V-erbA-Related Protein EAR-1