DAX-1 Orphan Nuclear Receptor

**Definition:** An orphan nuclear receptor that is implicated in regulation of steroidogenic pathways. It is unlike most orphan nuclear receptors in that it appears to lack an essential DNA-binding domain and instead acts as a transcriptional co-repressor. Mutations in the gene Dax-1 cause congenital adrenal hypoplasia.

**Tree numbers:** - D12.776.826.209.059 - D12.776.930.780.625.186

**Synonyms:** - NR0B1 Protein - DSS-AHC Critical Region on the X Chromosome, Gene 1 Protein - Nuclear Receptor NR0B1 - Nuclear Receptor 0B1 - Nuclear Receptor DAX-1 - Nuclear Receptor Subfamily 0, Group B, Member 1