Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome

**Definition:** A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc7, have been shown to mediate protein-protein interactions, suggesting that Apc8 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.

**Tree numbers:** - D08.811.464.938.750.092.996 - D12.776.167.024.996

**Synonyms:** - Anapc8 - Apc8 Subunit, Anaphase-Promoting Complex