Des-Gamma Carboxyprothrombin

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Des-gamma carboxyprothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein is involved in blood coagulation. This form of prothrombin is not efficiently converted to the active enzyme thrombin because it lacks gamma-carboxyglutamyl residues. These modified glutamyl residues are absent because of either vitamin K deficiency or inhibition of vitamin K activity that, in turn, inhibits the enzyme that carboxylates these residues, vitamin K-dependent gamma-carboxylase.

**Synonyms:** - DCP - Des-Gamma-Carboxy Prothrombin - PIVKA-II - Protein Induced by Vitamin K Absence or Antagonist II - Protein Induced by Vitamin K Absence-II - Protein Induced by Vitamin K Absence/Antagonist-II