Daunorubicinol

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** An anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicinol exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)

**Synonyms:** - 13-Dihydrodaunomycin - 13-Dihydrodaunorubicin - 13-Hydroxydaunomycin - 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(1-hydroxyethyl)-1-methoxy-, (8S-cis)- - DAUNORUBICINOL - Daunomycinol - Daunorubicineal - Duborimycin - Leukaemomycin D