Monosialotetrahexosylganglioside

**Semantic type:** Chemical Viewed Functionally|Immunologic Factor

**Definition:** A glycosphingolipid containing a sialic acid residue found in neuronal cell membranes, with potential neuroprotective and neuroregenerative activities. Upon administration, monosialotetrahexosylganglioside, also called GM-1, is able to both prevent neurologic damage and induce regeneration of damaged neurons through neurotrophic repair mechanisms, enhancement of the production of neutrophins, and augmenting neurite outgrowth. In addition, GM-1 exerts anti-excitotoxic activity, prevents necrosis, and improves neuronal recovery and function.

**Synonyms:** - GANGLIOSIDE GM1 - GM-1 - GM1 - Ganglioside GM-1 - Monosialoanglioside GM1