Elsamitrucin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. (NCI04)

**Synonyms:** - 10-O-Elsaminosylelsarosylchartarin - BBM 2478A - BMY-28090 - BRN 5214813 - Benzo(h)(1)benzopyrano(5,4,3-cde)(1)ebnzopyran-5,12-dione,10((2-O-(2-amino-2,6-dideoxy-3-O-methyl-alpha-D-galactopyranosyl)-6-deoxy-3-C-methyl-beta-D-galactopyranosyl)oxy)-6-hydroxy-1-methyl - ELSAMITRUCIN - Elsamicin A - Elsamitrucina - Elsamitrucine - Elsamitrucinum