Etoposide Phosphate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent. (NCI04)

**Synonyms:** - ETOPOSIDE PHOSPHATE - Etopophos - Etopophos - etoposide phosphate