Topoisomerase Inhibitor

**Semantic type:** Chemical Viewed Functionally

**Definition:** Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis.

**Synonyms:** - DNA Topoisomerase Inhibitors - Topoisomerase Inhibitors - topoisomerase inhibitor