HC-Toxin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A host-specific toxin from the maize pathogen Cochliobolus carbonum. An inhibitor of histone deacetylase, it is a cyclic tetrapeptide containing an epoxide alpha-amino acid. Inhibition of histone deacetylase is sensitive to mercaptoethanol treatment.

**Synonyms:** - Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl) - Cyclo(D-Pro-L-Ala-D-Ala-L-Aeo)