IGH/CRLF2 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation, either t(X;14)(p22;q32) or t(Y;14)(p11;q32), which fuses the transcriptional enhancers of the IGH gene locus with regulatory regions of the CRLF2 gene. This rearrangement is associated with acute lymphoblastic leukemia and expression of this fusion gene results in overexpression of the cytokine receptor-like factor 2 protein.

**Synonyms:** - IGH-CRLF2 Fusion Gene - IGH::CRLF2 Fusion Gene