IGH Locus Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal rearrangement involving the long arm of chromosome 14 (specifically 14q32). Most rearrangements involving 14q32 result in the juxtaposition of a strong transcriptional enhancer from the immunoglobulin heavy chain (IGH) gene locus with the promoter region for another gene; this promoter exchange process leads to overexpression or aberrant expression of the protein encoded by the fusion partner and is associated with various B-cell malignancies.

**Synonyms:** - IGH Fusion Gene - Immunoglobulin Heavy Chain Locus Fusion Gene - Immunoglobulin Heavy Locus Fusion Gene