Nucleoside Analog DFP-10917

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A deoxycytosine analog with potential antineoplastic activity. Upon administration, DFP-10917 is phosphorylated to generate its nucleotide form that functions as a deoxycytosine mimic and is incorporated into DNA in tumor cells. This causes DNA strand breaks during polymerization due to beta-elimination during the fidelity checkpoint, which results in G2/M phase-arrest and tumor cell apoptosis.

**Synonyms:** - 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine - DFP-10917