E3 Ubiquitin-Protein Ligase HACE1

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** E3 ubiquitin-protein ligase HACE1 (909 aa, ~102 kDa) is encoded by the human HACE1 gene. This protein is involved in the regulation of both the ubiquitination and subsequent degradation of small GTPases, which modulates Golgi membrane dynamics.

**Synonyms:** - EC 2.3.2.26 - EC 6.3.2.-, Formerly - HECT Domain and Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1 - HECT Domain- and Ankyrin Repeat-Containing E3 Ubiquitin Protein Ligase 1