FLT3 Activation Loop Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A mutation in the region of the FLT3 gene that encodes the second tyrosine kinase domain of the receptor-type tyrosine-protein kinase FLT3 that causes the stabilization of the activation loop of the kinase domain. FLT3 activation loop mutations lead to constitutive tyrosine kinase activity and are associated with acute myeloid leukemia.

**Synonyms:** - FLT3 A-Loop Mutation - FLT3 Tyrosine Kinase Domain Mutation - FLT3 Tyrosine Kinase Domain Mutation - FLT3- TKD mutations - FLT3-ALM - FLT3-TKD Mutation - FLT3/TKD Mutation