Activating FLT3 Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the FLT3 gene that results in constitutive activation of receptor-type tyrosine-protein kinase FLT3 and its downstream signaling pathways.

**Synonyms:** - Activating CD135 Gene Mutation - Activating FLK2 Gene Mutation - Activating FLT3 Gene Mutant - Activating FMS-Related Tyrosine Kinase 3 Gene Mutation - FLT3 Activating Mutation