Rebeccamycin

**Semantic type:** Amino Acid, Peptide, or Protein|Antibiotic|Pharmacologic Substance

**Definition:** An indolocarbazole glycoside antineoplastic antibiotic isolated from the bacterium Saccharothrix aerocolonigenes. Rebeccamycin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04)

**Synonyms:** - 5H-Indolo[2, 3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12, 13-dihydro-12-(4-O-methyl-.beta.-D-glucopyranosyl)- - 5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione,1,11-dichloro-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl) - BRN 4732638 - REBECCAMYCIN - rebeccamycin