Core Binding Factor Acute Myeloid Leukemia

**Semantic type:** Neoplastic Process

**Definition:** Acute myeloid leukemia characterized by the presence of t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22). These cytogenetic abnormalities result in disruption of the transcription factor CBF, which is a regulator of normal hematopoiesis.

**Synonyms:** - CBF-AML