Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1

**Semantic type:** Neoplastic Process

**Definition:** An acute myeloid leukemia with t(8;21)(q22; q22.1) giving rise to RUNX1/RUNX1T1 fusion transcript and showing maturation in the neutrophil lineage. The bone marrow and the peripheral blood show large myeloblasts with abundant basophilic cytoplasm, often containing azurophilic granules. This type of AML is associated with good response to chemotherapy and high complete remission rate.

**Synonyms:** - AML with t(8;21)(q22;q22), RUNX1 RUNX1T1 - AML with t(8;21)(q22;q22); RUNX1-RUNX1T1 - AML with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 - Acute Myeloid Leukemia with RUNX1-RUNX1T1 Fusion - Acute Myeloid Leukemia with RUNX1::RUNX1T1 Fusion - Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1 - Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1-RUNX1T1 Fusion - Acute Myeloid Leukemia with t(8;21)(q22; q22.1); RUNX1::RUNX1T1 Fusion - Acute Myeloid Leukemia with t(8;21)(q22;q22) - Acute Myeloid Leukemia with t(8;21)(q22;q22)(AML1(CBFa)/ETO) - Acute Myeloid Leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1 - Acute Myeloid Leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1 - Acute Myeloid Leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1 - Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1::RUNX1T1 - Acute Myeloid Leukemia, t(8;21)(q22;q22) - Acute myeloid leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1