Tiazofurin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. (NCI04)

**Synonyms:** - 2-.beta.-D-Ribofuranosyl-4-thiazolecarboxamide - 2-.beta.-D-Ribofuranosylthiazole-4-carboxamide - 2-Beta-D-ribofuranosyl-4-thiazolecarboxamide - 2-Beta-D-ribofuranosylthiazole-4-carboxamide - 4-Thiazolecarboxamide, 2-.beta.-D-ribofuranosyl- (9CI) - 4-Thiazolecarboxamide, 2-Beta-D-ribofuranosyl- (9CI) - Riboxamide - TCAR - TIAZOFURIN - Tiazofurine - tiazofurin