Topoisomerase I/II Inhibitor NEV-801

**Semantic type:** Pharmacologic Substance

**Definition:** A multi-targeted agent with potential antineoplastic activity. Upon administration, NEV-801 appears to selectively inhibit topoisomerase (Topo) I and II, and activates hypoxia-inducible factor 1 (HIF-1) transcription and the expression of vascular endothelial growth factor (VEGF) mRNA. NEV-801 is also able to overcome multidrug resistance (MDR) 1-mediated resistance.

**Synonyms:** - NEV-801 - NEV-801 - NEV801 - TopI/II NEV-801