O6-Benzylguanine

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. (NCI04)

**Synonyms:** - 2-amino-6-(benzyloxy)purine - 2-amino-6-(phenylmethoxy)-9h-purine - 6-O-BENZYLGUANINE - 6-O-Benzylguanine - O(6)-Benzylguanine - O(6)-benzylguanine - O-6-Benzylguanine - O6-BG